Infusion of hydroxyethyl starch-containing fluids.

Assessment report for solutions for infusion containing hydroxyethyl starch

Fluid Therapy in Thoracic Surgery: A Zero-Balance Target is Always Best!

Clinical studies including various types of surgical procedures have clearly shown an association between high perioperative fluids infusion and poor clinical outcome as expressed by composite mortality-morbidity endpoints (1-3). Overzealous fluid infusion promotes wound infections/dehiscence, anastomotic leakage and cardiac overload. Besides these quantitative aspects, fluid composition also d...

The effect of 6% hydroxyethyl starch and desmopressin infusion on von Willebrand factor: ristocetin cofactor activity.

Hydroxyethyl starch is commonly used as a plasma volume expander in the surgical patient. Although it is generally considered a safe plasma substitution, some reports of an acquired von Willebrand's disease-like syndrome have been documented. To examine this further, von Willebrand factor: ristocetin cofactor activity (RCoF) was measured in two groups of patients perioperatively, following hydr...

Antioxidant potential of i.v. fluids.

In acute clinical settings where there may be a role for antioxidant therapy, patients receive large amounts of i.v. fluids which may have antioxidant activity. To investigate such effects the antioxidant capacity of nine i.v. fluids was measured (Gelofusine, Haemaccel, 20% mannitol, 4.5% human albumin solution, fresh frozen plasma, aprotinin, N-acetylcysteine and two hydroxyethyl starch soluti...

Influence of fluid infusion associated with high-volume blood loss on plasma propofol concentrations.

BACKGROUND It is common clinical practice to use fluid infusion to manage high-volume blood loss until a blood transfusion is performed. The authors investigated the influence of fluid infusion associated with blood loss on the pseudo-steady state propofol concentration. METHODS Twenty-seven swine were assigned to a lactated Ringer's solution group, a hydroxyethyl starch group, or a threefold...